Precautions for Titanium tetrachloride

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Submitted by admin on Mon, 10/15/2018 - 06:37

Name: Titanium tetrachloride
Molecular formula: Cl4Ti
CAS number: 7550-45-0
Structural formula: Titanium tetrachloride

Physical properties: Colorless or yellowish liquid, pungent sour, smoke in the air. The vapor pressure was 1.33 kPa (21.3 ° C), mp -24 ° C, boiling point 136.4 ° C, and d 1.726 g / cm 3 . It is soluble in THF, CH 2 Cl 2 , toluene.

Preparation and commodity: Titanium tetrachloride is sold in major reagent companies. Industrially, it is obtained by mixing titanium dioxide and carbon powder, and then introducing chlorine gas at 600 ° C.

Precautions: This reagent is very active, and it will emit white smoke when exposed to humid air. The first formed TiCl 4 · 5H 2 O is finally hydrolyzed to form hydrated titanium dioxide (titanium dioxide xH 2 O). A violent reaction occurs when exposed to water. Direct contact with liquid titanium tetrachloride can cause varying degrees of burns. Its soot has a strong stimulating effect on the respiratory mucosa. Mild poisoning has asthmatic bronchitis. In severe cases, breathing difficulties, respiratory pulse acceleration, elevated body temperature, cough, etc. can develop into pulmonary edema.

As a common Lewis acid, titanium tetrachloride has important applications in organic synthesis. Titanium tetrachloride has a strong affinity for oxygen and dehydration. In addition, titanium tetrachloride and a reducing agent can promote the McMurray reaction of the carbonyl compound, and the product of the reaction is closely related to the type of reducing agent and the reducing ability.

Due to the oxophilic nature of titanium tetrachloride, it can well activate the carbonyl compound to increase the electrophilicity of the carbonyl compound, thereby facilitating reaction with the nucleophile. Titanium tetrachloride promotes the reaction of a carbonyl compound with an amine to form an imine. 

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